N-[(1S)-1-{1-[(1R,3E)-1-acetylpent-3-en-1-yl]-1H-1,2,3-triazol-4-yl}-1,2-dimethylpropyl]benzamide

N-[(1S)-1-{1-[(1R,3E)-1-acetylpent-3-en-1-yl]-1H-1,2,3-triazol-4-yl}-1,2-dimethylpropyl]benzamide is an experimental small molecule inhibitor designed to target cathepsin S. Cathepsin S is a cysteine protease involved in antigen presentation and implicated in various inflammatory and autoimmune diseases as well as cancer. This compound belongs to a class of nonpeptidic nitrile inhibitors that show high selectivity for cathepsin S over other related cathepsins (B and L), but not over cathepsin K. The compound was developed using substrate activity screening methods and structure-guided design to optimize potency and selectivity[5][7]. It has not been approved for any indication or advanced beyond preclinical/early research stages.

Other names

CNP0562602.1CNP-0562602.1CNP 0562602.1H7JH-7JH 7J